چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خسرو ادیب کیا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 58240 |
| عنوان فارسی مقاله | بررسی خصوصیات فیزیکوشیمیایی و ضد میکروبی نانوذرات کربنات کلسیم حاوی جنتامایسین تهیه شده به روش میکروامولسیون |
| عنوان لاتین مقاله | Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded CaCO3 nanoparticles prepared via microemulsion method |
| ناشر | 5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S1773224716300089 |
| Gentamicin sulfate (GS)-loaded calcium carbonate (CaCO3) nanoparticles were studied as efficient delivery system against staphylococcus aureus (S. aureus), the most common bacteria in the bone infections. Nanoparticles were prepared via microemulsion method and characterized by dynamic light scattering, scanning electron microscopy, powder X-ray diffraction analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy and drug release profiles. The antibacterial effect against S. aureus was also investigated to determine the minimum inhibitory concentration (MIC) of the nanoparticles. The mean diameter of the drug-loaded nanoparticles and loading efficiency were found to be 113.0 nm and 38.6%, respectively. Based on PXRD and FTIR studies, both vaterite and calcite polymorphs of CaCO3 were formed during the preparation process. In vitro release profiles of the nanoparticles showed slow release pattern for 12 h. The nanoparticles revealed a similar antimicrobial effect against S. aureus compared to untreated GS. However, after 2 days of incubation, an increase in the growth diameter of streak cultures on the agar medium was observed in the plates containing drug solution, while no increase in the initial growth line was detected for GS-loaded CaCO3 nanoparticles. So therefore, GS-loaded CaCO3 nanoparticles exhibited appropriate physicochemical properties as well das a preserved antimicrobial effect against S. aureus. |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرزانه لطفی پور بناب | دوم |
| محمد برزگر جلالی | سوم |
| محمد حسین زرین تن | چهارم |
| خسرو ادیب کیا | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Physicochemical characterization and antimicrobial evaluation of gentamicin-loaded ....pdf | 1395/04/08 | 1178628 | دانلود |
