چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمد رضا علی پرستی خاصلویی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 58226 |
| عنوان فارسی مقاله | Interleukin-17A and interleukin-17F mRNA expression in peripheral blood mononuclear cells of patients with multiple sclerosis. |
| عنوان لاتین مقاله | Interleukin-17A and interleukin-17F mRNA expression in peripheral blood mononuclear cells of patients with multiple sclerosis. |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://iji.sums.ac.ir/december2010/a_1stiji_vol7_no4_2010.pdf |
| Interleukin-17A and interleukin-17F mRNA expression in peripheral blood mononuclear cells of patients with multiple sclerosis. BACKGROUND: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17-producing T cells which are considered as dominant effectors for inducing autoimmune tissue inflammation. OBJECTIVE:The objective of this study was to assess the role of IL-17A and IL-17F in MS pathogenesis. METHODS:We evaluated mRNA expression of IL-17A and IL-17F in thirty-five Iranian patients with relapsing-remitting MS (RRMS) and twenty-five healthy controls by Quantitative Real Time PCR. RESULTS:The results of this study showed a twenty-fold increase in the expression of IL-17A mRNA in MS patients compared to the control group (p < 0.0001). IL-17F mRNA expression in MS patients was thirty three-times greater than the control group (p = 0.0008). IL-17A mRNA expression in the periphery was positively correlated with the expression of IL-17F transcripts in MS patients and controls (p < 0.01and p < 0.05, respectively). CONCLUSION:These results indicate the critical role of Th17- mediated cytokines in the development of MS which was classically considered as a Th1-mediated disorder. The results of this study showed, for the first time, the importance of IL-17F in MS immunopathogenesis. |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهره بابالو | اول |
| مهدی فرهودی | سوم |
| محمد رضا علی پرستی خاصلویی | چهارم |
| بهزاد برادران | پنجم |
| شهره الماسی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| a_1stiji_vol7_no4_2010.pdf | 1395/04/07 | 13530 | دانلود |
