| ABSTRACT. Scabies is one of the three most common skin disorders in children, along with tinea and pyoderma. The
treatment of choice is still controversial. The aim of this study is to compare the efficacy of permethrin 5% cream vs.
crotamiton 10% cream in the treatment of scabies. In total, 350 patients with scabies were enrolled, and randomized into
two groups. The first group received permethrin 5% cream on two occasions with a one-week interval, while the second
group received topical crotamiton 10% cream and were told to apply this twice daily for five consecutive days. The
treatment was evaluated at intervals of 2 and 4 weeks, and the treatment was repeated if treatment failure was found at
the 2-week follow-up. Two applications of permethrin 5 % cream provided a cure rate of 70% at the 2-week follow-up,
which increased to 85% at the 4-week follow-up after repeating the treatment. Treatment with single applications of
crotamiton 10% cream was effective in 45% of patients at the 2-week follow-up, which increased to 65% at the 4-week
follow-up after this treatment was repeated. Two applications of permethrin 5% cream was as effective as single
applications of crotamiton 10% cream at the 2-week follow-up. After repeating the treatment, permethrin 5 % cream
was superior to crotamiton 10% cream at the 4-week follow up. |