چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | محمدرضا علیپور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات سل و بیماری های ریوی |
| کد مقاله | 58124 |
| عنوان فارسی مقاله | Tracheal Overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in Obese-Asthmatic Male Wistar Rats |
| عنوان لاتین مقاله | Tracheal Overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in Obese-Asthmatic Male Wistar Rats |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | بلی |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://ijbms.mums.ac.ir/article_6805_918.html |
| Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet‐induced obesity (DIO) on the expression levels of IL‐1β, IRAK‐1 and TRAF‐6 mRNA in male Wistar rats tracheal after sensitization with ovalbumin (OVA). Materials and Methods: Twenty male Wistar rats divided to four groups, included, control group with normal diet (C+ND), OVA‐sensitized group with normal diet (S+ND), control group with high‐fat diet (C+HFD), and OVA‐sensitized group with high‐fat diet (S+HFD). All animals fed for 8 weeks with standard pelts or high‐fat diet, and then were sensitized and challenged with OVA or saline for another 4 weeks with designed regimens. At the end of study, trachea isolated and examined for expression levels of IL‐1β, IRAK‐1 and TRAF‐6 mRNA with RT‐PCR method. Results: Diet‐induced obesity groups developed increased weight, obesity indexes and lipid profiles (P<0.05 to P<0.001). The expression levels of IL‐1β mRNA in OVA‐sensitization groups (S+ND and S+HFD) showed a significantly increased when compared with control group. Also in S+HFD group, expression level of TRAF‐6 mRNA was higher than other groups (P<0.001). IRAK‐1 expression level was high in S+HFD compared with control group.IL‐1β and TRAF‐6 mRNA correlated positively with obesity indexes. Conclusion: The results showed that DIO causes overexpression of IL‐1β, IRAK‐1 and TRAF‐6 mRNA in an experimental model of asthma. Our results suggested that in obese‐asthmatic conditions locally production and activation of pro‐inflammatory agents can be increased. These findings showed that possible mechanism for obesity‐asthma relationships. |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمدرضا علیپور | ششم |
| محمدرضا اصلانی | اول |
| رعنا کیهان منش | دوم |
| امیرمهدی خامنه | سوم |
| مهران مسگری عباسی | چهارم |
| مریم فلاحی | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tracheal overexpression.pdf | 1395/03/26 | 337294 | دانلود |
