Comparing the Efficacy of High and Low Doses of Vitamin A in Prevention of Bronchopulmonary Dysplasia

Comparing the Efficacy of High and Low Doses of Vitamin A in Prevention of Bronchopulmonary Dysplasia


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نویسندگان: منیژه مصطفی قره باغی , مجید محله ای

کلمات کلیدی: Bronchopulmonary dysplasia, Preterm infants, Prevention, Vitamin A.

نشریه: , 6 , 4 , 2016

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نویسنده ثبت کننده مقاله منیژه مصطفی قره باغی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه سلامت باروری زنان
کد مقاله 57926
عنوان فارسی مقاله Comparing the Efficacy of High and Low Doses of Vitamin A in Prevention of Bronchopulmonary Dysplasia
عنوان لاتین مقاله Comparing the Efficacy of High and Low Doses of Vitamin A in Prevention of Bronchopulmonary Dysplasia
ناشر 4
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق) International Journal of Pediatrics
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت http://ijp.mums.ac.ir/article_6868.html

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Background Bronchopulmonary dysplasia (BPD) is one of the most common serious squeal of preterm infants. It involves approximately one quarter of infants with birth weight less than 1500 grams and 30% of less than 1000 grams. Vitamin A has been shown to reduce BPD rate. We compared efficacy of low and high doses of vitamin A for prevention of BPD in very low birth weight preterm infants. Materials and Methods In a randomized clinical trial, 120 preterm infants with gestation age 32 weeks or less and birth weight less than 1,500 grams were enrolled in the study. Group A (n=60) received 1,500 IU vitamin A intramuscularly three times per week and group B (n=60) received 5,000 IU vitamin A intramuscularly 3 times/week. Vitamin A was continued for 4 weeks in all patients. Oxygen dependency at age 28 days after birth and at 36 weeks’ postmenstrual age was determined in all studied infants. Results The mean gestation age and birth weight in group A was 29.2 ± 2.1 weeks and 1095 ± 211 gr and in group B 28.7 ± 2.1week and 1147 ± 218 grams (P>0.05). Moderate to severe bronchopulmonary dysplasia was detected in 6 (10%) neonates in group A and 13(21.6%) infants in group B, P= 0.09. Mortality rate was 4 (6.6%) infants in group A and 3 (5%) patients in group B (P>0.05). Conclusion In our study, high and low doses of vitamin A were similar with respect to the BPD, intra-ventricular hemorrhage, and retinopathy of prematurity and total number of days for hospital stay in very low birth weight preterm infants.

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نویسنده نفر چندم مقاله
منیژه مصطفی قره باغیدوم
مجید محله ایاول

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