چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خسرو ادیب کیا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کاربردی دارویی |
| کد مقاله | 57415 |
| عنوان فارسی مقاله | بررسی خصوصیات فیزیکوشیمیایی و درون تنی نانوکمپوزیت های هیدروکسی آپاتیت بارگیری شده با تریامسینولون استوناید جهت درمان آرتریت روماتوئید |
| عنوان لاتین مقاله | Physicochemical characterization and in vivo evaluation of triamcinolone acetonide-loaded hydroxyapatite nanocomposites for treatment of rheumatoid arthritis |
| ناشر | 6 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.sciencedirect.com/science/article/pii/S0927776515304008 |
| The current study was aimed to investigate the anti-inflammatory effect of triamcinolone acetonide-loaded hydroxyapatite (TA-loaded HAp) nanocomposites in the arthritic rat model. The HApnanocomposites were synthesized through a chemical precipitation method and the drug was subse-quently incorporated into the nanocomposites using an impregnation method. The physicochemicalproperties as well as cytotoxicity of the prepared nanoformulation were examined as well. To evaluatethe therapeutic efficacy of the prepared nanoformulation, the various parameters such as paw volume,haematological parameters and histological studies were assessed in the arthritic rats. The nanocompos-ites with the particle size of 70.45 nm, pore size of 2.71 nm and drug loading of 41.94% were obtainedin this study. The specific surface area (aBET) as well as the volume of nitrogen adsorbed on one gramof HAp to complete the monolayer adsorption (Vm) were decreased after the drug loading process. Theprepared nanoformulation revealed the slower drug release profile compared to the pure drug. Fur-thermore, the obtained data from MTT assay showed that the TA-loaded nanocomposites had a lowercytotoxic effect on NIH-3T3 and CAOV-4 cell lines as compared to the pure drug. Furthermore, TA-loadedHAp nanocomposites demonstrated favorable effects on the paw volume as well as the haematologicaland histopathological abnormalities in the adjuvant-induced arthritic rats. Therefore, TA-loaded HApnanocomposites are potentially suggested for treatment of rheumatoid arthritis after further requiredevaluations. |
| نویسنده | نفر چندم مقاله |
|---|---|
| نسرین مالکی دیزجی | دوم |
| ژاله برار | سوم |
| محمد برزگر جلالی | چهارم |
| خسرو ادیب کیا | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Triamcinolone acetonide-loaded hydroxyapatite nanocomposites.pdf | 1394/12/15 | 2981129 | دانلود |
