چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خسرو ادیب کیا |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات بیوتکنولوژی(زیست فناوری) |
| کد مقاله | 57413 |
| عنوان فارسی مقاله | تهیه نانوذرات و نانوفیبرهای تریامسینولون استوناید- اودراجیت RS100: بررسی مورفولوژی و خصوصیات فیزیکوشیمیایی |
| عنوان لاتین مقاله | Triamcinolone acetonide–Eudragit RS100 nanofibers and nanobeads: Morphological and physicochemical characterization |
| ناشر | 7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ | خیر |
| عنوان نشریه (خارج از لیست فوق) | |
| نوع مقاله | Original Article |
| نحوه ایندکس شدن مقاله | ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://www.tandfonline.com/doi/full/10.3109/21691401.2014.953250#abstract |
| Context and objective: The aim of the present research was to fabricate triamcinolone acetonide (TA)-Eudragit RS100 nanostructures using the electrospraying method. Materials and methods: The physicochemical properties of the electrosprayed formulations as well as drug release patterns were assessed. The particle size and morphology were evaluated using scanning electron microscopy. X-ray crystallography and differential scanning calorimetry were alsoconductedtoinvestigatethecrystallinityandpolymorphic alterations of the drug in the formulations. Probable chemical interactions between the drug and the carrier during the preparation process were analyzed using FT-IR spectroscopy. The drug release kinetic was also considered to predict the release mechanism. Results and discussion: Increasing the concentration of injected polymer solution resulted in the formation of more fibers and fewer beads, with the particle diameter ranging from 60 nm to a few micrometers based on the drug: polymer ratio. The drug crystallinity was notably decreased during the electrospraying process; however, no interaction between drug and polymer was detected. The electrosprayed formulations with 1:10 drug: polymer ratio showed an almost similar drug release rate compared to the pure drug, while those with 1:5 ratio revealed slower release profiles. The release data were best fitted to the Weibull model, so that the corresponding shape factor values of the Weibull model were less than 0.75, indicating the diffusion controlled release mechanism. Conclusion: Our findings revealed that TA loaded Eudragit RS100 nanofibers and nanobeads were properly prepared by the electrospraying method, which is a simple, surfactant-free and cost effective technique for producing drug: polymer nanostructures. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سودابه داوران | دوم |
| خسرو ادیب کیا | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Triamcinolone acetonide Eudragit RS100-ACNN.pdf | 1394/12/13 | 850000 | دانلود |
