چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Ankylosing Spondylitis (AS) is a common cause of inflammatory arthritis. The disease is associated with the gene HLA-B27; however, only 1%–5% of HLA- B27-positive individuals develop ankylosing spondylitis, and there is increasing evidence to suggest that other genes must also be involved. Over the last few years, the development of high-throughput microarray-based single-nucleotide polymorphism (SNP) genotyping techniques and genome-wide association studies (GWAS) have helped to highlight non-HLA genetic risk factors associated with AS. In this study, we investigated the association between SNP rs10865331 and Ankylosing Spondylitis in Iranian Azari patients. 57 AS patients who fulfilled the selection criteria, were solicited sequentially at Tabriz University of Medical Sciences Hospitals, Tabriz, Iran. Also, 50 cases as control group were participated in this study. There were 45 men (79%) and 12 women (21%) in the patient group. Mean age of patients was 38 ± 10.4 years (ranging 20-62). The mean BASFI score of AS patients was 7.74. Also, the mean BASDAI score was 20.11.All of the patients were heterozygote for rs10865331 SNP. Also, all of the cases in the control group were heterozygote for rs10865331 SNP. This lack of association could be related to a small sample size or racial issues. Because of this, This SNP cannot have a diagnostic application in our population and therefore complementary study with larger sample size is necessary to unravel this intergenic AS-associated SNP. |
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| سوسن کلاهی | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| rib~56834~1445508265~2.ahadi.pdf | 1394/7/30 | 114401 | دانلود |
